Novel Drug Development Utilizing Transport Function of P-glycoprotein.
نویسندگان
چکیده
منابع مشابه
P-glycoprotein transporter in drug development
Drug discovery and development is a complex and time consuming process which requires multidisciplinary expertise (Pracha-yasittikul et al., 2015a). It is true that bioac-tive compounds will become useless if their pharmacokinetic properties are not adequate. Pharmacokinetic properties include absorption (A), distribution (D), metabolism (M), excretion (E) and toxicity (T), or ADMET. ADMET prop...
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Human P-glycoprotein (P-gp) is an ATP-binding cassette multidrug transporter that confers resistance to a wide range of chemotherapeutic agents in cancer cells by active efflux of the drugs from cells. P-gp also plays a key role in limiting oral absorption and brain penetration and in facilitating biliary and renal elimination of structurally diverse drugs. Thus, identification of drugs or new ...
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ژورنال
عنوان ژورنال: Drug Metabolism and Pharmacokinetics
سال: 1998
ISSN: 0916-1139
DOI: 10.2133/dmpk.13.287